2-(4-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethanamine
$1,100.00
CAS No.: 919724-53-1
Catalog No.: 197324
Purity: 95%
MF: C13H20ClN3
MW: 253.777
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C(C=C1)C(CN)N1CCN(CC1)C
Catalog No.: 197324
Purity: 95%
MF: C13H20ClN3
MW: 253.777
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C(C=C1)C(CN)N1CCN(CC1)C
2-(4-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethanamine; CAS No.: 919724-53-1; 2-(4-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethanamine. PROPERTIES: This chloro-piperazinyl-substituted ethanamine features molecular formula C??H??ClN? with molecular weight 278.79 g/mol. It generally appears as a white crystalline powder. Soluble in polar protic solvents like methanol and water. Melting point approximately 90-95 C. Exhibits IR absorption for amine (~3300-3000 cm??) and C-Cl groups (~600-500 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a chloro-piperazinyl-substituted ethanamine, 2-(4-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethanamine is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the piperazinyl group provides valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its amine functionality enables conjugation to fluorophores via reductive amination (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the piperazinyl group contributes to improved flame retardancy and mechanical properties (Polymer International).
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