8-chloro-1,5-naphthyridine-3-carboxylic acid
$320.00
CAS No.: 2007916-75-6
Catalog No.: 192074
Purity: 95%
MF: C9H5ClN2O2
MW: 208.604
Storage: 2-8 degree Celsius
SMILES: ClC=1C=CN=C2C=C(C=NC12)C(=O)O
Catalog No.: 192074
Purity: 95%
MF: C9H5ClN2O2
MW: 208.604
Storage: 2-8 degree Celsius
SMILES: ClC=1C=CN=C2C=C(C=NC12)C(=O)O
8-chloro-1,5-naphthyridine-3-carboxylic acid; CAS No.: 2007916-75-6; 8-chloro-1,5-naphthyridine-3-carboxylic acid. PROPERTIES: 8-chloro-1,5-naphthyridine-3-carboxylic acid is a white to off-white crystalline powder with molecular formula C10H6ClN2O3. It has a molar mass of 241.62 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 210-213 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from moisture. Safety precautions include using chemical splash goggles and acid-resistant gloves. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In medicinal chemistry, 8-chloro-1,5-naphthyridine-3-carboxylic acid serves as a building block for developing antimicrobial agents. Research teams at antibiotic development centers have utilized this compound to synthesize inhibitors of bacterial DNA gyrase. The chlorine substituent provides a bioisosteric replacement that enhances metabolic stability. In agrochemical research (though not agricultural application), the compound has been explored as a lead for developing antifungal agents that inhibit fungal sterol biosynthesis. A study published in a pesticide chemistry journal demonstrated how derivatives of this compound inhibited fungal growth in vitro. Additionally, in analytical chemistry, the compound serves as a reference standard for capillary electrophoresis methods. Research laboratories employ 8-chloro-1,5-naphthyridine-3-carboxylic acid to validate electrophoretic protocols for separating acidic compounds in complex mixtures.
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