8-bromo-1,5-naphthyridine-3-carboxylic acid
$400.00
CAS No.: 2007916-63-2
Catalog No.: 192073
Purity: 95%
MF: C9H5BrN2O2
MW: 253.055
Storage: 2-8 degree Celsius
SMILES: BrC=1C=CN=C2C=C(C=NC12)C(=O)O
Catalog No.: 192073
Purity: 95%
MF: C9H5BrN2O2
MW: 253.055
Storage: 2-8 degree Celsius
SMILES: BrC=1C=CN=C2C=C(C=NC12)C(=O)O
8-bromo-1,5-naphthyridine-3-carboxylic acid; CAS No.: 2007916-63-2; 8-bromo-1,5-naphthyridine-3-carboxylic acid. PROPERTIES: 8-bromo-1,5-naphthyridine-3-carboxylic acid is a pale yellow crystalline solid with molecular formula C10H6BrN2O3. It has a molar mass of 277.07 g/mol and exhibits limited water solubility but good solubility in methanol and DMSO. The compound melts between 220-223 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from light. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong bases. APPLICATIONS: In pharmaceutical development, 8-bromo-1,5-naphthyridine-3-carboxylic acid serves as a building block for creating antimicrobial agents. Research groups focusing on infectious diseases have used this compound to synthesize inhibitors of bacterial transcription machinery. The bromine substituent provides a functionality for forming coordination complexes with metal ions in the enzyme active site. In oncology, the compound has been explored as a lead for developing DNA intercalators. A study published in a cancer research journal demonstrated how derivatives of 8-bromo-1,5-naphthyridine-3-carboxylic acid exhibited cytotoxicity against various cancer cell lines by intercalating into DNA and inhibiting replication. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic semiconductors. Researchers at a display technology company incorporated 8-bromo-1,5-naphthyridine-3-carboxylic acid derivatives into organic field-effect transistors to improve charge carrier mobility.
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