5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde hydrochloride
$425.00
CAS No.: NA
Catalog No.: 192762
Purity: 95%
MF: C9H11ClN2O
MW: 198.653
Storage: 2-8 degree Celsius
SMILES: Cl.N1=C(C=CC=2CCCNC12)C=O
Catalog No.: 192762
Purity: 95%
MF: C9H11ClN2O
MW: 198.653
Storage: 2-8 degree Celsius
SMILES: Cl.N1=C(C=CC=2CCCNC12)C=O
5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde hydrochloride; 5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde hydrochloride. PROPERTIES: This tetrahydro naphthyridine aldehyde salt has molecular formula C7H12ClN2O. It generally appears as a white crystalline powder. The 5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde hydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 200-205 C (with decomposition), and it has a molecular weight of approximately 176.65 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The hydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde hydrochloride functions as a valuable intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the aldehyde group provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The tetrahydro naphthyridine ring enhances metabolic stability by preventing oxidative degradation. Additionally, the compound serves as a building block in the preparation of bioconjugates for drug delivery systems where the aldehyde group reacts with targeting moieties, as described in pharmaceutical sciences journals. The aldehyde group can be further functionalized through reduction or oximation reactions to produce various derivatives for chemical research applications.
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