3-bromo-8-chloro-1,7-naphthyridine
$200.00
CAS No.: 1260670-05-0
Catalog No.: 192106
Purity: 95%
MF: C8H4BrClN2
MW: 243.491
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NC2=C(N=CC=C2C1)Cl
Catalog No.: 192106
Purity: 95%
MF: C8H4BrClN2
MW: 243.491
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NC2=C(N=CC=C2C1)Cl
3-bromo-8-chloro-1,7-naphthyridine; CAS No.: 1260670-05-0; 3-bromo-8-chloro-1,7-naphthyridine. PROPERTIES: 3-bromo-8-chloro-1,7-naphthyridine is a white crystalline powder with molecular formula C9H5BrClN2. It has a molar mass of 277.50 g/mol and shows limited water solubility but good solubility in methanol and acetone. The compound melts between 170-173 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from moisture. Safety precautions include using chemical splash goggles and acid-resistant gloves. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong bases. APPLICATIONS: In medicinal chemistry, 3-bromo-8-chloro-1,7-naphthyridine serves as a building block for developing antimicrobial agents. Research teams at antibiotic development centers have utilized this compound to synthesize inhibitors of bacterial cell wall synthesis enzymes. The bromine and chlorine substituents provide bioisosteric replacements that enhance metabolic stability. In agrochemical research (though not agricultural application), the compound has been explored as a lead for developing antifungal agents that inhibit fungal sterol biosynthesis. A study published in a pesticide chemistry journal demonstrated how derivatives of this compound inhibited fungal growth in vitro. Additionally, in analytical chemistry, the compound serves as a reference standard for capillary electrophoresis methods. Research laboratories employ 3-bromo-8-chloro-1,7-naphthyridine to validate electrophoretic protocols for separating acidic compounds in complex mixtures.
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