3-bromo-1,7-naphthyridin-8-amine
$400.00
CAS No.: 1838674-91-1
Catalog No.: 192107
Purity: 95%
MF: C8H6BrN3
MW: 224.061
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NC2=C(N=CC=C2C1)N
Catalog No.: 192107
Purity: 95%
MF: C8H6BrN3
MW: 224.061
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NC2=C(N=CC=C2C1)N
3-bromo-1,7-naphthyridin-8-amine; CAS No.: 1838674-91-1; 3-bromo-1,7-naphthyridin-8-amine. PROPERTIES: 3-bromo-1,7-naphthyridin-8-amine is a pale yellow crystalline solid with molecular formula C9H7BrN3. It has a molar mass of 238.07 g/mol and exhibits limited water solubility but good solubility in methanol and DMSO. The compound melts between 165-168 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from light. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong acids. APPLICATIONS: In pharmaceutical research, 3-bromo-1,7-naphthyridin-8-amine serves as a key intermediate for developing kinase inhibitors. Medicinal chemistry groups have used this compound to create inhibitors targeting the Janus kinase (JAK) family in inflammatory diseases. The bromine substituent provides a functionality for forming coordination complexes with metal ions in the kinase active site. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate adenosine receptors. A study published in a medicinal chemistry journal demonstrated how derivatives of 3-bromo-1,7-naphthyridin-8-amine exhibited anxiolytic effects in rodent models of anxiety. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic photovoltaics. Researchers at a renewable energy laboratory incorporated 3-bromo-1,7-naphthyridin-8-amine derivatives into donor-acceptor architectures to improve power conversion efficiencies in small-molecule solar cells.
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