(S)-5-phenylmorpholin-3-one
$200.00
CAS No.: 1052209-96-7
Catalog No.: 192743
Purity: 95%
MF: C10H11NO2
MW: 177.203
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)[C@H]1COCC(N1)=O
Catalog No.: 192743
Purity: 95%
MF: C10H11NO2
MW: 177.203
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)[C@H]1COCC(N1)=O
(S)-5-phenylmorpholin-3-one; CAS No.: 1052209-96-7; (S)-5-phenylmorpholin-3-one. PROPERTIES: This phenyl-substituted morpholinone has molecular formula C11H14N2O. It typically appears as a white crystalline powder. The (S)-5-phenylmorpholin-3-one demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 90-95 C, and it has a molecular weight of approximately 194.24 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may hydrolyze to the corresponding alcohol upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The (S)-5-phenylmorpholin-3-one functions as a key intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the morpholinone ring provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The phenyl group enhances metabolic stability by preventing oxidative degradation. Additionally, the compound serves as a building block in the preparation of chiral ligands for asymmetric catalysis, achieving enantiomeric excesses above 95% in certain hydrogenation reactions as described in synthetic chemistry journals. The ketone group can be further functionalized through reduction or alkylation reactions to produce various derivatives for chemical research applications.
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