(R)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
$450.00
CAS No.: 1390715-99-7
Catalog No.: 192731
Purity: 95%
MF: C11H13NO3
MW: 207.229
Storage: 2-8 degree Celsius
SMILES: COC=1C=C2CCN[C@H](C2=CC1)C(=O)O
Catalog No.: 192731
Purity: 95%
MF: C11H13NO3
MW: 207.229
Storage: 2-8 degree Celsius
SMILES: COC=1C=C2CCN[C@H](C2=CC1)C(=O)O
(R)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; CAS No.: 1390715-99-7; (R)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid. PROPERTIES: This methoxy-substituted tetrahydroisoquinoline carboxylic acid has molecular formula C10H13N2O2. It typically appears as a white crystalline powder. The (R)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 130-135 C, and it has a molecular weight of approximately 191.22 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may decarboxylate upon exposure to high temperatures above 200 C. In case of spillage, neutralization with a mild base followed by disposal as hazardous waste is recommended. APPLICATIONS: The (R)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid serves as a valuable intermediate in the synthesis of adenosine receptor antagonists for cardiovascular indications where the methoxy group provides essential lipophilicity for receptor binding (as reported in medicinal chemistry literature). The carboxylic acid group forms ionic interactions with receptor residues. Additionally, the compound functions as a building block in the preparation of bioconjugates for drug delivery systems where the carboxylic acid group reacts with amino groups on targeting moieties, as described in pharmaceutical sciences journals. The carboxylic acid can be further functionalized through esterification or amidation reactions to produce various derivatives for chemical research applications.
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