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8-methoxyisoquinoline-5-carboxylic acid; CAS No.: 1516652-25-7; 8-methoxyisoquinoline-5-carboxylic acid. PROPERTIES: 8-methoxyisoquinoline-5-carboxylic acid appears as a white to off-white solid with molecular weight 203.2 g/mol. It has a melting point between 210-215 C and shows limited aqueous solubility but good solubility in DMSO. Proper storage requires a tightly sealed container at room temperature away from acidic vapors. Safety precautions include wearing protective gloves and eye protection as this compound may cause skin and eye irritation. APPLICATIONS: This methoxy-substituted isoquinoline carboxylic acid is employed in the synthesis of HIV-1 reverse transcriptase inhibitors. The carboxylic acid group forms critical interactions with the enzyme's active site as described in antiviral research papers. In materials science, 8-methoxyisoquinoline-5-carboxylic acid derivatives have found use in creating self-assembled monolayers for surface modification. According to materials chemistry journals, the isoquinoline core promotes adsorption onto metal surfaces while the carboxylic acid group imparts chemical resistance.