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8-fluoroisoquinolin-1-amine; CAS No.: 1369071-72-6; 8-fluoroisoquinolin-1-amine. PROPERTIES: 8-fluoroisoquinolin-1-amine is a crystalline solid with molecular formula C9H6FNN. It has a melting point between 155-160 C and exhibits moderate solubility in ethanol and methanol. The compound should be stored in a tightly sealed container at room temperature away from acidic vapors. Safety considerations include using appropriate engineering controls and standard PPE to prevent skin absorption and inhalation. APPLICATIONS: This fluorinated isoquinoline amine is employed in the synthesis of dual serotonin-norepinephrine reuptake inhibitors. The amine group provides critical interactions with neurotransmitter transporters as described in psychopharmacology research. In chemical biology, 8-fluoroisoquinolin-1-amine serves as a building block for creating fluorescent sensors. According to bioanalytical chemistry journals, the isoquinoline scaffold's natural fluorescence allows for detection of specific analytes with limits approaching picomolar concentrations.