7-bromo-1,2-dihydroisoquinolin-3(4H)-one
$250.00
CAS No.: 943751-93-7
Catalog No.: 196250
Purity: 95%
MF: C9H8BrNO
MW: 226.073
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=C2CC(NCC2=C1)=O
Catalog No.: 196250
Purity: 95%
MF: C9H8BrNO
MW: 226.073
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=C2CC(NCC2=C1)=O
7-bromo-1,2-dihydroisoquinolin-3(4H)-one; CAS No.: 943751-93-7; 7-bromo-1,2-dihydroisoquinolin-3(4H)-one. PROPERTIES: This compound features a 7-bromo-1,2-dihydroisoquinolin-3(4H)-one structure, combining a bromine atom and a dihydroisoquinolinone framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 231.1 g/mol (C8H7BrN2O). The melting point ranges between 150-155 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 7-Bromo-1,2-dihydroisoquinolin-3(4H)-one serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 7-bromo-1,2-dihydroisoquinolin-3(4H)-one structure allows for participation in various reactions, including palladium-catalyzed cross-coupling reactions at the bromine position and nucleophilic substitution at the ketone carbonyl. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The bromine atom provides a handle for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Organic Chemistry journals, focusing on the development of novel bromoisoquinolinone derivatives based on the 7-bromo-1,2-dihydroisoquinolin-3(4H)-one scaffold.
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