4-methylisoquinolin-3-amine
$300.00
CAS No.: 7697-66-7
Catalog No.: 196249
Purity: 95%
MF: C10H10N2
MW: 158.204
Storage: 2-8 degree Celsius
SMILES: CC1=C(N=CC2=CC=CC=C12)N
Catalog No.: 196249
Purity: 95%
MF: C10H10N2
MW: 158.204
Storage: 2-8 degree Celsius
SMILES: CC1=C(N=CC2=CC=CC=C12)N
4-methylisoquinolin-3-amine; CAS No.: 7697-66-7; 4-methylisoquinolin-3-amine. PROPERTIES: This compound presents a 4-methylisoquinolin-3-amine structure, combining a methyl substituent and an amine group on the isoquinoline framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 160.2 g/mol (C9H9N2). The melting point ranges between 100-105 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4-Methylisoquinolin-3-amine serves as a specialized intermediate in pharmaceutical research. Its 4-methylisoquinolin-3-amine structure enables diverse reactivity patterns, including nucleophilic substitution at the amine group and electrophilic substitution at the isoquinoline ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The methyl substituent provides steric and electronic effects that influence binding interactions with biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 4-methylisoquinolin-3-amine scaffold for improved biological activity and target engagement.
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