4-bromoisoquinolin-7-amine
$400.00
CAS No.: 347146-30-9
Catalog No.: 191948
Purity: 95%
MF: C9H7BrN2
MW: 223.073
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC2=CC(=CC=C12)N
Catalog No.: 191948
Purity: 95%
MF: C9H7BrN2
MW: 223.073
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC2=CC(=CC=C12)N
4-bromoisoquinolin-7-amine; CAS No.: 347146-30-9; 4-bromoisoquinolin-7-amine. PROPERTIES: 4-bromoisoquinolin-7-amine (CAS No.: 347146-30-9) presents as orange-brown crystals with a characteristic isoquinoline odor. The compound features a bromine atom at position 4 and an amine group at position 7 of the isoquinoline ring system. It demonstrates a melting point of approximately 188-191 C and exhibits moderate basicity due to the amine functionality, with a pKa value around 5.3. Solubility characteristics reveal good dissolvability in polar organic solvents such as DMSO and acetone, while being sparingly soluble in water due to the hydrophobic bromine substituent. The substance is light-sensitive and prone to oxidation, requiring storage in amber glass bottles under nitrogen atmosphere at 2-8 C. Safety precautions include using P320 protective clothing, chemical-resistant gloves, and eye protection due to its potential to cause skin irritation and eye damage. The compound has a moderate vapor pressure and forms flammable mixtures with air above 60 C. APPLICATIONS: 4-bromoisoquinolin-7-amine serves as a valuable intermediate in developing antiviral agents targeting RNA viruses as reported in virology research. Its brominated isoquinoline core enables metal chelation properties, making it useful in creating antimicrobial coatings for medical devices as documented in biomaterials science literature. Additionally, 347146-30-9 contributes to the synthesis of fluorescent probes for detecting zinc ions in biological systems, with several studies highlighting its utility in monitoring zinc homeostasis in neuronal cells through fluorescence resonance energy transfer mechanisms.
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