1-chloro-4-fluoroisoquinoline
$400.00
CAS No.: 435278-06-1
Catalog No.: 191968
Purity: 95%
MF: C9H5ClFN
MW: 181.597
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=C(C2=CC=CC=C12)F
Catalog No.: 191968
Purity: 95%
MF: C9H5ClFN
MW: 181.597
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=C(C2=CC=CC=C12)F
1-chloro-4-fluoroisoquinoline; CAS No.: 435278-06-1;1-chloro-4-fluoroisoquinoline. PROPERTIES: 1-chloro-4-fluoroisoquinoline represents a halogenated isoquinoline derivative with molecular formula C9H5ClFN. This colorless liquid exhibits characteristic properties of aromatic heterocycles with halogen substitution. The 1-chloro-4-fluoroisoquinoline compound has a boiling point around 220-225 C at atmospheric pressure and demonstrates good solubility in organic solvents like acetone and ethyl acetate. The dual halogenation pattern imparts unique reactivity, with the chlorine and fluorine atoms positioned para to each other on the isoquinoline ring. Storage recommendations include maintaining in amber glass bottles away from moisture and direct light, with temperature control below 15 C. Safety measures necessitate working in well-ventilated areas and using chemical-resistant gloves due to its potential to cause respiratory and dermal irritation. The compound is classified under Xn (harmful) and R36/37/38 risk phrases according to European safety regulations. APPLICATIONS: The 1-chloro-4-fluoroisoquinoline structure functions as a versatile synthetic intermediate in fine chemical manufacturing. In agrochemical development, it serves as a precursor for synthesizing isoquinoline-based herbicides and fungicides, as described in pesticide chemistry literature. The dual halogen substitution pattern facilitates diverse cross-coupling reactions, making 1-chloro-4-fluoroisoquinoline valuable in preparing bioisosteric replacements in medicinal chemistry. Additionally, its use in developing fluorescent probes for bioimaging applications has been explored in analytical chemistry research, leveraging the isoquinoline scaffold's natural fluorescence properties documented in photochemical studies.
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