1-chloro-4-fluoroisoquinolin-5-amine
$350.00
CAS No.: 928665-23-0
Catalog No.: 191970
Purity: 95%
MF: C9H6ClFN2
MW: 196.612
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=C(C=2C(=CC=CC12)N)F
Catalog No.: 191970
Purity: 95%
MF: C9H6ClFN2
MW: 196.612
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=C(C=2C(=CC=CC12)N)F
1-chloro-4-fluoroisoquinolin-5-amine; CAS No.: 928665-23-0;1-chloro-4-fluoroisoquinolin-5-amine. PROPERTIES: 1-chloro-4-fluoroisoquinolin-5-amine is a multifunctional heterocycle with molecular formula C9H6ClFN2. This crystalline powder typically melts between 190-195 C and displays moderate solubility in protic solvents while being more soluble in aprotic polar solvents. The compound's amine functionality confers basic character, with a pKa value around 3.8 for the protonated form. The chlorine and fluorine substituents create an electron-deficient aromatic system, influencing reactivity patterns. Recommended storage involves keeping in a desiccator with appropriate drying agents, protected from light and moisture at temperatures below 10 C. Safety protocols emphasize using PPE including safety goggles and lab coats, as the compound may cause serious eye damage and skin irritation. It carries GHS labels with H314 and H318 hazard statements reflecting its corrosive nature and potential for causing severe eye burns. APPLICATIONS: The 1-chloro-4-fluoroisoquinolin-5-amine molecule has emerged as a critical intermediate in the synthesis of next-generation kinase inhibitors. In oncology research, it serves as a core structure for developing targeted cancer therapies, as evidenced by recent patents in medicinal chemistry. The amine group enables further functionalization through reductive alkylation or amide bond formation. Additionally, 1-chloro-4-fluoroisoquinolin-5-amine derivatives have shown promise in antiviral applications, particularly against RNA viruses, according to virology research publications. The compound's ability to participate in hydrogen bonding interactions makes it valuable in designing molecules with optimized pharmacokinetic profiles, as discussed in drug design literature focusing on bioavailability enhancement strategies.
Reviews
Write Your Own Review