2-(4-amino-1-oxoisoindolin-2-yl)pentanedioic acid
$500.00
CAS No.: 295357-66-3
Catalog No.: 192723
Purity: 95%
MF: C13H14N2O5
MW: 278.264
Storage: 2-8 degree Celsius
SMILES: NC1=C2CN(C(C2=CC=C1)=O)C(C(=O)O)CCC(=O)O
Catalog No.: 192723
Purity: 95%
MF: C13H14N2O5
MW: 278.264
Storage: 2-8 degree Celsius
SMILES: NC1=C2CN(C(C2=CC=C1)=O)C(C(=O)O)CCC(=O)O
2-(4-amino-1-oxoisoindolin-2-yl)pentanedioic acid; CAS No.: 295357-66-3; 2-(4-amino-1-oxoisoindolin-2-yl)pentanedioic acid. PROPERTIES: This amino-substituted isoindolinone dicarboxylic acid has molecular formula C11H11N3O4. It typically appears as a white crystalline powder. The 2-(4-amino-1-oxoisoindolin-2-yl)pentanedioic acid demonstrates limited water solubility but good solubility in DMSO and DMF. Its melting point ranges between 220-225 C (with decomposition), and it has a molecular weight of approximately 253.22 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may decarboxylate upon exposure to high temperatures above 200 C. In case of spillage, neutralization with a mild base followed by disposal as hazardous waste is recommended. APPLICATIONS: The 2-(4-amino-1-oxoisoindolin-2-yl)pentanedioic acid functions as a valuable intermediate in the synthesis of HIV protease inhibitors where the isoindolinone group provides essential hydrogen bonding interactions with enzyme residues (as detailed in medicinal chemistry literature). The dicarboxylic acid groups form ionic interactions with catalytic residues. Additionally, the compound serves as a building block in the preparation of bioconjugates for drug delivery systems where the carboxylic acid groups react with amino groups on targeting moieties, as described in pharmaceutical sciences journals. The amino group can be further functionalized through acylation or amidation reactions to produce various derivatives for chemical research applications.
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