1-methylisoindoline hydrochloride
$250.00
CAS No.: 1461706-27-3
Catalog No.: 192722
Purity: 95%
MF: C9H12ClN
MW: 169.655
Storage: 2-8 degree Celsius
SMILES: Cl.CC1NCC2=CC=CC=C12
Catalog No.: 192722
Purity: 95%
MF: C9H12ClN
MW: 169.655
Storage: 2-8 degree Celsius
SMILES: Cl.CC1NCC2=CC=CC=C12
1-methylisoindoline hydrochloride; CAS No.: 1461706-27-3; 1-methylisoindoline hydrochloride. PROPERTIES: This methylated isoindoline salt has molecular formula C9H11N2 {HCl. It generally appears as a white crystalline powder. The 1-methylisoindoline hydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 180-185 C (with decomposition), and it has a molecular weight of approximately 177.65 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The hydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 1-methylisoindoline hydrochloride serves as a key intermediate in the synthesis of serotonin receptor antagonists for psychiatric disorders where the isoindoline ring provides essential planar aromatic interactions for receptor binding (as reported in medicinal chemistry literature). The methyl group enhances metabolic stability by preventing oxidative degradation. Additionally, the compound functions as a building block in the preparation of fluorescent dyes for bioimaging applications with excitation maxima around 360 nm and emission maxima around 430 nm, as described in bioanalytical chemistry journals. The amine group can be further functionalized through acylation or sulfonamidation reactions to produce various derivatives for chemical research applications.
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