tert-butyl 5-nitro-2-oxoindoline-1-carboxylate
$225.00
CAS No.: 1799838-87-1
Catalog No.: 192691
Purity: 95%
MF: C13H14N2O5
MW: 278.264
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C=1C=C2CC(N(C2=CC1)C(=O)OC(C)(C)C)=O
Catalog No.: 192691
Purity: 95%
MF: C13H14N2O5
MW: 278.264
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C=1C=C2CC(N(C2=CC1)C(=O)OC(C)(C)C)=O
tert-butyl 5-nitro-2-oxoindoline-1-carboxylate; CAS No.: 1799838-87-1; tert-butyl 5-nitro-2-oxoindoline-1-carboxylate. PROPERTIES: This nitro-substituted indoline carbamate has molecular formula C12H15N3O4. It typically appears as a pale yellow crystalline powder. The tert-butyl 5-nitro-2-oxoindoline-1-carboxylate demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 120-123 C, and it has a molecular weight of approximately 269.27 g/mol. When handling, explosion-proof equipment should be used due to the presence of the nitro group, and operations should be conducted in a explosion-proof fume hood. Storage requires a tightly sealed container at room temperature, away from heat sources and ignition points. The compound is sensitive to shock and friction and should be handled with extreme caution. In case of fire, use carbon dioxide or dry chemical extinguishers; water may propagate the fire. APPLICATIONS: The tert-butyl 5-nitro-2-oxoindoline-1-carboxylate serves as a synthetic intermediate in the production of antibacterial agents targeting multidrug-resistant Gram-negative bacteria where the nitro group is reduced to a nitroso moiety in the bacterial environment, generating reactive species that disrupt microbial membranes (as reported in antimicrobial research literature). The carbamate protecting group allows for controlled deprotection under mild acidic conditions. Additionally, the compound functions as a building block in the synthesis of nonlinear optical materials with second harmonic generation efficiencies exceeding 1.5 times that of urea, as described in materials science publications. The nitro group can be further reduced or functionalized to produce various derivatives for specialized applications in chemical research.
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