5-chloro-1-methylindolin-2-one
$400.00
CAS No.: 41192-33-0
Catalog No.: 192698
Purity: 95%
MF: C9H8ClNO
MW: 181.622
Storage: 2-8 degree Celsius
SMILES: ClC=1C=C2CC(N(C2=CC1)C)=O
Catalog No.: 192698
Purity: 95%
MF: C9H8ClNO
MW: 181.622
Storage: 2-8 degree Celsius
SMILES: ClC=1C=C2CC(N(C2=CC1)C)=O
5-chloro-1-methylindolin-2-one; CAS No.: 41192-33-0; 5-chloro-1-methylindolin-2-one. PROPERTIES: This chlorinated indolinone has molecular formula C8H7ClN2O. It generally appears as a white crystalline powder. The 5-chloro-1-methylindolin-2-one demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 140-143 C, and it has a molecular weight of approximately 186.6 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong bases and may decompose upon exposure to high temperatures above 180 C. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 5-chloro-1-methylindolin-2-one functions as a valuable intermediate in the synthesis of kinase inhibitors for cancer therapy where the chloro group provides essential binding interactions with kinase residues (as detailed in medicinal chemistry literature). The methyl group enhances metabolic stability by preventing oxidative degradation. Additionally, the compound serves as a building block in the preparation of agrochemicals with fungicidal activity, though this application is mentioned only for informational purposes per your request. The ketone group can be further functionalized through reduction or alkylation reactions to produce various derivatives for chemical research applications.
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