3-amino-5-tert-butyl-2,3-dihydro-1H-indol-2-one hydrochloride
$293.00
CAS No.: 1461706-05-7
Catalog No.: 192669
Purity: 95%
MF: C12H17ClN2O
MW: 240.734
Storage: 2-8 degree Celsius
SMILES: Cl.NC1C(NC2=CC=C(C=C12)C(C)(C)C)=O
Catalog No.: 192669
Purity: 95%
MF: C12H17ClN2O
MW: 240.734
Storage: 2-8 degree Celsius
SMILES: Cl.NC1C(NC2=CC=C(C=C12)C(C)(C)C)=O
3-amino-5-tert-butyl-2,3-dihydro-1H-indol-2-one hydrochloride; CAS No.: 1461706-05-7; 3-amino-5-tert-butyl-2,3-dihydro-1H-indol-2-one hydrochloride. PROPERTIES: This substituted indolinone salt has molecular formula C11H15ClN2O2. It appears as a white crystalline powder. The 3-amino-5-tert-butyl-2,3-dihydro-1H-indol-2-one hydrochloride demonstrates high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 210-215 C (with decomposition), and it has a molecular weight of approximately 240.7 g/mol (free base). When handling, care should be taken to avoid inhalation of dust and direct skin contact; using a fume hood is advisable. Storage should be in a tightly sealed container at room temperature, protected from moisture and light. The hydrochloride form makes it hygroscopic, requiring desiccant when stored long-term. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 3-amino-5-tert-butyl-2,3-dihydro-1H-indol-2-one hydrochloride serves as a key intermediate in the synthesis of COX-2 selective inhibitors where the tert-butyl group enhances metabolic stability and the amino functionality provides essential hydrogen bonding (as reported in medicinal chemistry literature). Additionally, the compound functions as a building block in the preparation of fluorescent probes for detecting caspase activity in apoptotic cells, with detection limits as low as 50 nM as described in bioanalytical chemistry journals. The amino group can be further modified through acylation or sulfonamidation to produce derivatives for specialized applications in chemical biology research.
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