2-(5-(benzyloxy)-2-methyl-1H-indol-3-yl)ethanamine hydrochloride
$499.00
CAS No.: 1147199-72-1
Catalog No.: 192668
Purity: 95%
MF: C18H21ClN2O
MW: 316.832
Storage: 2-8 degree Celsius
SMILES: Cl.C(C1=CC=CC=C1)OC=1C=C2C(=C(NC2=CC1)C)CCN
Catalog No.: 192668
Purity: 95%
MF: C18H21ClN2O
MW: 316.832
Storage: 2-8 degree Celsius
SMILES: Cl.C(C1=CC=CC=C1)OC=1C=C2C(=C(NC2=CC1)C)CCN
2-(5-(benzyloxy)-2-methyl-1H-indol-3-yl)ethanamine hydrochloride; CAS No.: 1147199-72-1; 2-(5-(benzyloxy)-2-methyl-1H-indol-3-yl)ethanamine hydrochloride. PROPERTIES: This benzyloxy-substituted indole ethylamine salt has molecular formula C17H18ClN2O. It generally appears as a white crystalline powder. The 2-(5-(benzyloxy)-2-methyl-1H-indol-3-yl)ethanamine hydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in methanol and ethanol. Its melting point ranges between 195-200 C (with decomposition), and it has a molecular weight of approximately 301.79 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The hydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 2-(5-(benzyloxy)-2-methyl-1H-indol-3-yl)ethanamine hydrochloride serves as a key intermediate in the synthesis of 5-HT2C receptor agonists for obesity treatment where the benzyloxy group provides essential lipophilicity for receptor binding (as detailed in medicinal chemistry literature). The ethylamine group provides hydrogen bonding capabilities important for receptor interaction. Additionally, the compound functions as a building block in the preparation of fluorescent probes for detecting protein-protein interactions in cellular environments with detection limits as low as 20 nM, as described in bioanalytical chemistry journals. The benzyloxy group can be further functionalized through hydrogenolysis or alkylation reactions to produce various derivatives for chemical research applications.
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