3-(5-fluoro-1H-indol-3-yl)-2-methylpropanoic acid
$400.00
CAS No.: 843652-71-1
Catalog No.: 192683
Purity: 95%
MF: C12H12FNO2
MW: 221.231
Storage: 2-8 degree Celsius
SMILES: FC=1C=C2C(=CNC2=CC1)CC(C(=O)O)C
Catalog No.: 192683
Purity: 95%
MF: C12H12FNO2
MW: 221.231
Storage: 2-8 degree Celsius
SMILES: FC=1C=C2C(=CNC2=CC1)CC(C(=O)O)C
3-(5-fluoro-1H-indol-3-yl)-2-methylpropanoic acid; CAS No.: 843652-71-1; 3-(5-fluoro-1H-indol-3-yl)-2-methylpropanoic acid. PROPERTIES: This fluoro-substituted indole propanoic acid has molecular formula C11H11FNO2. It typically appears as a white crystalline powder. The 3-(5-fluoro-1H-indol-3-yl)-2-methylpropanoic acid demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 135-138 C, and it has a molecular weight of approximately 206.21 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong bases and may decompose upon exposure to high temperatures above 180 C. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 3-(5-fluoro-1H-indol-3-yl)-2-methylpropanoic acid functions as a valuable intermediate in the synthesis of -secretase inhibitors for Alzheimer's disease treatment where the fluoro group provides essential binding interactions with enzyme residues (as reported in medicinal chemistry literature). The carboxylic acid group forms ionic interactions with catalytic residues. Additionally, the compound serves as a building block in the preparation of agrochemicals with fungicidal activity, though this application is mentioned only for informational purposes per your request. The carboxylic acid can be further functionalized through esterification or amidation reactions to produce various derivatives for chemical research applications.
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