ethyl 7-bromo-1H-indazole-3-carboxylate
$375.00
CAS No.: 885279-56-1
Catalog No.: 192664
Purity: 95%
MF: C10H9BrN2O2
MW: 269.098
Storage: 2-8 degree Celsius
SMILES: BrC=1C=CC=C2C(=NNC12)C(=O)OCC
Catalog No.: 192664
Purity: 95%
MF: C10H9BrN2O2
MW: 269.098
Storage: 2-8 degree Celsius
SMILES: BrC=1C=CC=C2C(=NNC12)C(=O)OCC
ethyl 7-bromo-1H-indazole-3-carboxylate; CAS No.: 885279-56-1; ethyl 7-bromo-1H-indazole-3-carboxylate. PROPERTIES: This brominated indazole ester has molecular formula C10H9BrN2O2. It generally appears as a white crystalline powder. The ethyl 7-bromo-1H-indazole-3-carboxylate exhibits moderate solubility in common organic solvents like ethyl acetate and chloroform but limited water solubility. Its melting point ranges between 95-98 C, and it has a molecular weight of approximately 263.09 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may hydrolyze to the corresponding carboxylic acid upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The ethyl 7-bromo-1H-indazole-3-carboxylate functions as a valuable intermediate in the synthesis of FGFR kinase inhibitors for cancer therapy where the bromine atom provides essential binding interactions with kinase domains (as detailed in medicinal chemistry literature). The ester group allows for further functionalization through hydrolysis or transesterification reactions. Additionally, the compound serves as a building block in the preparation of liquid crystal materials with specific dielectric properties, useful in display technologies with response times below 25 milliseconds as described in materials chemistry journals. The bromine atom can be replaced with various substituents through Suzuki-Miyaura coupling reactions to produce diverse derivatives for chemical research applications.
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