5-(trifluoromethoxy)-1H-indazole
$250.00
CAS No.: 105391-76-2
Catalog No.: 192646
Purity: 95%
MF: C8H5F3N2O
MW: 202.135
Storage: 2-8 degree Celsius
SMILES: FC(OC=1C=C2C=NNC2=CC1)(F)F
Catalog No.: 192646
Purity: 95%
MF: C8H5F3N2O
MW: 202.135
Storage: 2-8 degree Celsius
SMILES: FC(OC=1C=C2C=NNC2=CC1)(F)F
5-(trifluoromethoxy)-1H-indazole; CAS No.: 105391-76-2; 5-(trifluoromethoxy)-1H-indazole. PROPERTIES: This trifluoromethoxy-substituted indazole has molecular formula C8H6F3N3O. It typically appears as a white to off-white crystalline solid. The 5-(trifluoromethoxy)-1H-indazole demonstrates moderate solubility in common organic solvents like DCM and THF but limited water solubility. Its melting point is approximately 108-112 C, and it has a molecular weight of about 217.15 g/mol. When handling, care should be taken to avoid inhalation of dust and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong bases and may decompose upon exposure to high temperatures above 150 C. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 5-(trifluoromethoxy)-1H-indazole serves as a valuable intermediate in the synthesis of serotonin receptor antagonists for psychiatric disorders where the trifluoromethoxy group provides essential lipophilicity for blood-brain barrier penetration (as reported in pharmacology literature). Additionally, the compound functions as a building block in the preparation of agrochemicals with herbicidal activity, though this application is mentioned only for informational purposes per your request. The trifluoromethoxy group can be further functionalized through nucleophilic substitution reactions to produce various derivatives for specialized applications in chemical research. Its aromatic system makes it suitable for use in organic photovoltaic materials as an electron-withdrawing component, contributing to improved power conversion efficiencies as described in materials science publications.
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