5-fluoro-1H-indazole-3-carboxylic acid methyl ester
$200.00
CAS No.: 78155-73-4
Catalog No.: 111054
Purity: 95%
MF: C9H7FN2O2
MW: 194.165
Storage: 2-8 degree Celsius
SMILES: COC(=O)C1=NNC2=C1C=C(F)C=C2
Catalog No.: 111054
Purity: 95%
MF: C9H7FN2O2
MW: 194.165
Storage: 2-8 degree Celsius
SMILES: COC(=O)C1=NNC2=C1C=C(F)C=C2
5-fluoro-1H-indazole-3-carboxylic acid methyl ester; CAS No.: 78155-73-4; ChemShuttle's portfolio includes fluorinated building blocks such as 5-fluoro-1H-indazole-3-carboxylic acid methyl ester. This ester-protected indazole derivative combines electron-deficient fluorine substitution with a carboxylate handle for further functionalization. The 3-carboxylate group allows amide bond formation or hydrolysis to corresponding acids, while the 5-fluoro modification enhances metabolic stability in vivo. Our custom chemical synthesis companies employ continuous flow chemistry to optimize the SNAr fluorination step, achieving >99% regioselectivity. This compound serves as crucial intermediate for PET tracer development and kinase inhibitor libraries. We provide technical support including computed logD values (predicted 2.1) and plasma protein binding data to streamline lead candidate selection.
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