1H-indazole-7-carboxamide
$200.00
CAS No.: 312746-74-0
Catalog No.: 196198
Purity: 95%
MF: C8H7N3O
MW: 161.164
Storage: 2-8 degree Celsius
SMILES: N1N=CC2=CC=CC(=C12)C(=O)N
Catalog No.: 196198
Purity: 95%
MF: C8H7N3O
MW: 161.164
Storage: 2-8 degree Celsius
SMILES: N1N=CC2=CC=CC(=C12)C(=O)N
1H-indazole-7-carboxamide; CAS No.: 312746-74-0; 1H-indazole-7-carboxamide. PROPERTIES: This compound features a 1H-indazole-7-carboxamide structure, combining an amide group and an indazole ring system. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 179.2 g/mol (C10H8N4O). The melting point ranges between 190-195 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing gloves, eye protection, and a lab coat. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 1H-Indazole-7-carboxamide serves as a valuable intermediate in pharmaceutical and chemical synthesis. Its 1H-indazole-7-carboxamide structure enables participation in various reactions, including amide bond formation, hydrolysis to carboxylic acid, and nucleophilic substitution at the indazole ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The amide group provides hydrogen-bonding capabilities for improved target binding. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on the development of novel indazole derivatives based on the 1H-indazole-7-carboxamide scaffold.
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