1H-indazole-4-carbonitrile
$327.00
CAS No.: 861340-10-5
Catalog No.: 111061
Purity: 95%
MF: C8H5N3
MW: 143.149
Storage: 2-8 degree Celsius
SMILES: N#CC1=CC=CC2=C1C=NN2
Catalog No.: 111061
Purity: 95%
MF: C8H5N3
MW: 143.149
Storage: 2-8 degree Celsius
SMILES: N#CC1=CC=CC2=C1C=NN2
1H-indazole-4-carbonitrile; CAS No.: 861340-10-5; Specializing in nitrile-containing pharma building blocks, ChemShuttle offers 1H-indazole-4-carbonitrile for protease inhibitor development. The electron-withdrawing cyano group at position 4 activates adjacent positions for nucleophilic aromatic substitution while increasing metabolic stability. This compound's calculated PSA of 65 ?2 and moderate lipophilicity (cLogP 1.3) make it ideal for optimizing oral bioavailability. Our chemical synthesis companies employ state-of-the-art cyanation techniques using Pd-catalyzed cross-coupling for superior regiocontrol. The nitrile functionality allows conversion to tetrazoles or amides through click chemistry approaches. We provide stability data under accelerated ICH conditions (40 C/75% RH) and DVS analysis for formulation studies.
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