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imidazo[1,2-b]pyridazin-6-ol
$350.00
CAS No.: 57470-54-9
Catalog No.: 196189
Purity: 95%
MF: C6H5N3O
MW: 135.126
Storage: 2-8 degree Celsius
SMILES: N=1C=CN2N=C(C=CC21)O
Catalog No.: 196189
Purity: 95%
MF: C6H5N3O
MW: 135.126
Storage: 2-8 degree Celsius
SMILES: N=1C=CN2N=C(C=CC21)O
imidazo[1,2-b]pyridazin-6-ol; CAS No.: 57470-54-9; imidazo[1,2-b]pyridazin-6-ol. PROPERTIES: This compound features a imidazo[1,2-b]pyridazin-6-ol structure, combining a hydroxyl group and an imidazo[1,2-b]pyridazine ring system. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 167.1 g/mol (C7H5N3O). The melting point ranges between 180-185 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety precautions include wearing gloves, eye protection, and a lab coat. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: Imidazo[1,2-b]pyridazin-6-ol is employed in pharmaceutical research as a lead compound. Its imidazo[1,2-b]pyridazin-6-ol structure enables diverse substitution patterns, making it suitable for developing enzyme inhibitors and receptor modulators. The hydroxyl group can undergo etherification, esterification, or oxidation to carboxylic acid. In medicinal chemistry, it is used to create bioactive molecules targeting the central nervous system and inflammatory pathways. The imidazo[1,2-b]pyridazine ring provides metabolic stability and bioisosteric replacement capabilities. This compound also functions as a building block in the synthesis of fluorescent probes for bioimaging applications, where the conjugated system contributes to fluorescence properties. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the imidazo[1,2-b]pyridazin-6-ol scaffold for improved biological activity and target engagement.
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