ethyl 2-(4-fluorophenyl)-4-methyl-1H-imidazole-5-carboxylate
$200.00
CAS No.: 1153734-59-8
Catalog No.: 197805
Purity: 95%
MF: C13H13FN2O2
MW: 248.257
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(C=C1)C=1NC(=C(N1)C)C(=O)OCC
Catalog No.: 197805
Purity: 95%
MF: C13H13FN2O2
MW: 248.257
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(C=C1)C=1NC(=C(N1)C)C(=O)OCC
ethyl 2-(4-fluorophenyl)-4-methyl-1H-imidazole-5-carboxylate; CAS No.: 1153734-59-8;ethyl 2-(4-fluorophenyl)-4-methyl-1H-imidazole-5-carboxylate. PROPERTIES: Ethyl 2-(4-fluorophenyl)-4-methyl-1H-imidazole-5-carboxylate is a fluorinated imidazole ester with a molecular weight of 255.25 g/mol. This white crystalline solid has a melting point between 110-113 C. The molecule features an imidazole ring substituted with a 4-fluorophenyl group at position 2 and a methyl group at position 4, with the carboxylate function esterified to ethyl at position 5. It demonstrates moderate solubility in common organic solvents such as methanol and acetone but limited water solubility. Proper storage involves keeping in tightly sealed containers at room temperature, protected from light and moisture. Safety considerations include the fluorine substituent's potential to cause skin irritation and the ester group's flammability. Proper protective equipment should be utilized during handling. APPLICATIONS: This compound primarily serves as a building block in the synthesis of agrochemicals and pharmaceuticals, where the fluorinated imidazole structure provides structural diversity for receptor interactions. In medicinal chemistry, it has been employed in developing antimicrobial agents targeting bacterial and fungal pathogens and has shown utility in creating herbicides with selective activity against grassy weeds. The imidazole-5-carboxylate ester structure has also been explored in materials science for developing fluorescent probes, leveraging the electron-withdrawing fluorine atom to tune optical properties. These applications are documented in publications from the Journal of Medicinal Chemistry and Dyes and Pigments.
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