(R)-3-hydroxydihydrofuran-2(3H)-one
$300.00
CAS No.: 56881-90-4
Catalog No.: CP0058
Purity: 95%
MF: C4H6O3
MW: 102.089
Storage: 2-8 degree Celsius
SMILES: O[C@H]1C(OCC1)=O
Catalog No.: CP0058
Purity: 95%
MF: C4H6O3
MW: 102.089
Storage: 2-8 degree Celsius
SMILES: O[C@H]1C(OCC1)=O
CAS NO.: 56881-90-4;(R)-3-hydroxydihydrofuran-2(3H)-one. PROPERTIES: This chiral furanone derivative appears as a colorless liquid with a molecular weight of approximately 118.1 g/mol. The (R)-3-hydroxydihydrofuran-2(3H)-one combines a chiral center with hydroxy and ketone functionalities in a five-membered ring system. It exhibits limited aqueous solubility but good dissolution in lower alcohols and ketones. Stability characterization reveals vulnerability to acid-catalyzed ring-opening and base-promoted tautomerism. The compound requires storage at 2-8 degree Celsius in borosilicate glass containers. Safety measures include using powder hoods with HEPA filtration and wearing cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The (R)-3-hydroxydihydrofuran-2(3H)-one functions as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals (excluding agricultural applications). Its chiral furanone framework provides essential steric and electronic properties for creating complex molecules. Research teams utilize this compound as a starting material for creating macrolide antibiotics and antiviral agents. The hydroxy and ketone groups offer versatile handles for further functionalization through glycosylation and amination reactions. Additionally, the compound undergoes Michael addition reactions for constructing polyfunctionalized systems. Its chiral nature makes it valuable in the development of enantiomerically pure compounds for asymmetric catalysis.
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