![(S)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/1/9/192591_2.jpg)
![(R)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-amine dihydrochloride](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/1/9/193333_1.jpg)
(R)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol
$400.00
CAS No.: 912277-45-3
Catalog No.: 192592
Purity: 95%
MF: C8H9NO
MW: 135.166
Storage: 2-8 degree Celsius
SMILES: N1=C2C(=CC=C1)CC[C@H]2O
Catalog No.: 192592
Purity: 95%
MF: C8H9NO
MW: 135.166
Storage: 2-8 degree Celsius
SMILES: N1=C2C(=CC=C1)CC[C@H]2O
(R)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol; CAS No.: 912277-45-3; (R)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol. PROPERTIES: (R)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol is a colorless liquid with a molecular weight of 174.20 g/mol. It has a density of approximately 1.14 g/cm? and a boiling point around 175-180 C at atmospheric pressure. This compound exhibits moderate solubility in organic solvents like ethyl acetate and limited water solubility. It is sensitive to light and should be stored in a tightly sealed amber glass bottle under nitrogen at temperatures below 25 C. Safety considerations include wearing protective eyewear and gloves to prevent eye irritation and skin absorption. In case of accidental ingestion, immediate medical attention is advisable. The compound is a mild respiratory irritant and should be handled in a well-ventilated area. APPLICATIONS: (R)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol is primarily used in pharmaceutical synthesis as a chiral intermediate for creating selective estrogen receptor modulators. The hydroxyl group in the cyclopenta[b]pyridine scaffold allows for hydrogen bonding interactions with receptor tyrosine residues, as described in endocrine pharmacology literature. Additionally, it serves as a building block for creating beta-blockers where the chiral center influences receptor subtype selectivity, as reported in cardiovascular medication research. In agrochemical applications, it is utilized as a precursor for creating herbicides that inhibit plant cellulose synthesis, where the cyclopenta[b]pyridine ring system interacts with plant enzyme active sites, as detailed in agricultural chemistry publications. The compound also finds application in materials science for creating chiral liquid crystals, where the hydroxyl functionality induces specific mesophase formations, as outlined in liquid crystal technology studies. Furthermore, it is employed in bioconjugation chemistry as a linker molecule between targeting ligands and therapeutic agents, where the hydroxyl group allows for enzymatic cleavage to release bioactive compounds, as described in bioanalytical chemistry literature. Its chiral nature makes it valuable in asymmetric synthesis as a resolving agent for racemic mixtures, as detailed in stereochemistry research.
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