6-bromo-2H-chromen-2-one
$365.00
CAS No.: 19063-55-9
Catalog No.: 196234
Purity: 95%
MF: C9H5BrO2
MW: 225.041
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C=CC(OC2=CC1)=O
Catalog No.: 196234
Purity: 95%
MF: C9H5BrO2
MW: 225.041
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C=CC(OC2=CC1)=O
6-bromo-2H-chromen-2-one; CAS No.: 19063-55-9; 6-bromo-2H-chromen-2-one. PROPERTIES: This compound presents a 6-bromo-2H-chromen-2-one structure, combining a bromine atom and a chromen-2-one framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 255.0 g/mol (C9H6BrO2). The melting point ranges between 150-155 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 6-Bromo-2H-chromen-2-one serves as a specialized intermediate in pharmaceutical research. Its 6-bromo-2H-chromen-2-one structure enables diverse reactivity patterns, including palladium-catalyzed cross-coupling reactions at the bromine position and nucleophilic substitution at the chromen-2-one ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, G protein-coupled receptors, and proteases. The bromine atom provides a handle for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 6-bromo-2H-chromen-2-one scaffold for improved biological activity and pharmacokinetic properties.
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