5,7-difluorochroman-4-ol
$400.00
CAS No.: 917248-51-2
Catalog No.: 197263
Purity: 95%
MF: C9H8F2O2
MW: 186.157
Storage: 2-8 degree Celsius
SMILES: FC1=C2C(CCOC2=CC(=C1)F)O
Catalog No.: 197263
Purity: 95%
MF: C9H8F2O2
MW: 186.157
Storage: 2-8 degree Celsius
SMILES: FC1=C2C(CCOC2=CC(=C1)F)O
5,7-difluorochroman-4-ol; CAS No.: 917248-51-2; 5,7-difluorochroman-4-ol. PROPERTIES: This difluoro-substituted chroman features molecular formula C?H?F?O? with molecular weight 190.15 g/mol. It generally appears as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Melting point approximately 90-95 C. Exhibits IR absorption for hydroxyl groups (~3300 cm??) and C-F groups (~1300-1100 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a difluoro-substituted chroman, 5,7-difluorochroman-4-ol is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the chroman core of these compounds, where the fluoro substituents provide enhanced binding affinity for the kinase hinge region as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its chroman framework enables conjugation to fluorophores with enhanced photostability (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the fluoro substituents contribute to improved flame retardancy and mechanical properties (Polymer International).
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