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3-(piperidin-4-yl)benzo[d]oxazol-2(3H)-one
$200.00
CAS No.: 215878-20-9
Catalog No.: 196322
Purity: 95%
MF: C12H14N2O2
MW: 218.256
Storage: 2-8 degree Celsius
SMILES: N1CCC(CC1)N1C(OC2=C1C=CC=C2)=O
Catalog No.: 196322
Purity: 95%
MF: C12H14N2O2
MW: 218.256
Storage: 2-8 degree Celsius
SMILES: N1CCC(CC1)N1C(OC2=C1C=CC=C2)=O
3-(piperidin-4-yl)benzo[d]oxazol-2(3H)-one; CAS No.: 215878-20-9; 3-(piperidin-4-yl)benzo[d]oxazol-2(3H)-one. PROPERTIES: This compound presents a 3-(piperidin-4-yl)benzo[d]oxazol-2(3H)-one structure, combining a piperidine group and a benzo[d]oxazolone framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 233.2 g/mol (C13H12N2O2). The melting point ranges between 190-195 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 3-(Piperidin-4-yl)benzo[d]oxazol-2(3H)-one serves as a specialized intermediate in pharmaceutical research. Its 3-(piperidin-4-yl)benzo[d]oxazol-2(3H)-one structure enables diverse reactivity patterns, including nucleophilic substitution at the piperidine nitrogen and electrophilic substitution at the benzo[d]oxazolone ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The piperidine group provides hydrogen-bonding capabilities for improved target binding. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 3-(piperidin-4-yl)benzo[d]oxazol-2(3H)-one scaffold for improved biological activity and target engagement.
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