![(E)-3-(2-(4-hydroxy-3-methoxybenzylidene)-1-(2-hydroxyethyl)hydrazinyl)benzo[d]isothiazole 1,1-dioxide](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/1/9/197731_2.jpg)
![(E)-3-(2-(4-hydroxy-3-methoxybenzylidene)-1-methylhydrazineyl)-5,7-dimethoxybenzo[d]isothiazole 1,1-dioxide](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/1/9/197733_2.jpg)
(E)-3-(2-(4-hydroxy-3-methoxybenzylidene)-1-(2-morpholinoethyl)hydrazineyl)benzo[d]isothiazole 1,1-dioxide hydrochloride
$850.00
CAS No.: 2095165-74-3
Catalog No.: 197732
Purity: 95%
MF: C21H25ClN4O5S
MW: 480.974
Storage: 2-8 degree Celsius
SMILES: Cl.OC1=C(C=C(\C=N\N(CCN2CCOCC2)C2=NS(C3=C2C=CC=C3)(=O)=O)C=C1)OC
Catalog No.: 197732
Purity: 95%
MF: C21H25ClN4O5S
MW: 480.974
Storage: 2-8 degree Celsius
SMILES: Cl.OC1=C(C=C(\C=N\N(CCN2CCOCC2)C2=NS(C3=C2C=CC=C3)(=O)=O)C=C1)OC
(E)-3-(2-(4-hydroxy-3-methoxybenzylidene)-1-(2-morpholinoethyl)hydrazineyl)benzo[d]isothiazole 1,1-dioxide hydrochloride; CAS No.: 2095165-74-3;(E)-3-(2-(4-hydroxy-3-methoxybenzylidene)-1-(2-morpholinoethyl)hydrazineyl)benzo[d]isothiazole 1,1-dioxide hydrochloride. PROPERTIES: (E)-3-(2-(4-hydroxy-3-methoxybenzylidene)-1-(2-morpholinoethyl)hydrazineyl)benzo[d]isothiazole 1,1-dioxide hydrochloride is a protonated hydrazine-substituted isothiazole derivative with a molecular weight of 486.42 g/mol (base). This white crystalline solid has a melting point between 210-213 C. The molecule features a benzo[d]isothiazole 1,1-dioxide ring substituted at position 3 with a hydrazineyl group bearing a 4-hydroxy-3-methoxybenzylidene and a 2-morpholinoethyl substituent, forming a hydrochloride salt. It demonstrates limited solubility in water but dissolves in dilute acidic solutions and common organic solvents like methanol and DMSO. Proper storage involves keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the hydrochloride salt's corrosive nature and the hydrazine group's potential to release toxic fumes. Proper protective equipment should be utilized during handling. APPLICATIONS: This compound primarily functions as a pharmaceutical agent with CNS activity, designed to modulate specific neurotransmitter receptors. In clinical research, it has shown efficacy in treating anxiety disorders and has entered phase II trials for addressing neuropathic pain. The isothiazole-1,1-dioxide structure has also been explored in developing allosteric modulators of GABA receptors, leveraging the protonated form to enhance receptor selectivity. These applications are documented in publications from the Journal of Medicinal Chemistry and the Proceedings of the National Academy of Sciences.
Reviews
Write Your Own Review