![(E)-3-(2-(4-hydroxy-3-methoxybenzylidene)-1-methylhydrazineyl)-5,7-dimethoxybenzo[d]isothiazole 1,1-dioxide](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/1/9/197733_2.jpg)
![lithium 2-(benzo[d]thiazol-2-yl)acetate](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/1/8/188745_2.jpg)
4-bromobenzo[d]thiazol-2(3H)-one; CAS No.: 73443-85-3;4-bromobenzo[d]thiazol-2(3H)-one. PROPERTIES: 4-bromobenzo[d]thiazol-2(3H)-one is a brominated thiazole derivative with a molecular weight of 247.06 g/mol. This white crystalline solid has a melting point between 185-188 C. The molecule features a benzo[d]thiazole ring system with a bromo substituent at position 4 and a ketone group at position 2. It demonstrates limited solubility in common organic solvents such as methanol and acetone but is sparingly soluble in water. Proper storage involves keeping in tightly sealed containers at room temperature, protected from light and moisture. Safety considerations include the bromine substituent's potential to cause skin irritation and the ketone group's moderate toxicity. Proper protective equipment should be utilized during handling. APPLICATIONS: This compound primarily functions as a building block in the synthesis of agrochemicals and pharmaceuticals, where the brominated thiazolone structure provides essential binding affinity to target enzymes. In medicinal chemistry, it has been employed in developing antimicrobial agents targeting bacterial and fungal pathogens and has shown utility in creating herbicides with selective activity against grassy weeds. The thiazolone scaffold has also been explored in materials science for developing fluorescent probes, leveraging the electron-deficient thiazole core to tune optical properties. These applications are documented in publications from the Journal of Medicinal Chemistry and the Journal of Fluorescence.
Reviews
Write Your Own Review