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7-bromobenzo[d]isoxazol-3-amine
$320.00
CAS No.: 1260860-32-9
Catalog No.: LT0075
Purity: 95%
MF: C7H5BrN2O
MW: 213.034
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=CC=2C(=NOC21)N
Catalog No.: LT0075
Purity: 95%
MF: C7H5BrN2O
MW: 213.034
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=CC=2C(=NOC21)N
CAS NO.: 1260860-32-9;7-bromobenzo[d]isoxazol-3-amine. PROPERTIES: This brominated heterocycle presents as a white crystalline solid with a molecular weight of approximately 231.0 g/mol. The 7-bromobenzo[d]isoxazol-3-amine combines a bromine substituent with an isoxazole ring and amine functionality. It exhibits limited aqueous solubility but good dissolution in polar aprotic solvents like DMSO and DMF. Stability characterization reveals vulnerability to acid-catalyzed ring-opening and base-promoted hydrolysis of the amine group, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 7-bromobenzo[d]isoxazol-3-amine serves as a key intermediate in the synthesis of various pharmaceuticals. Its isoxazole framework provides opportunities for directed metalation and cross-coupling reactions. Research teams utilize this compound as a starting material for creating kinase inhibitors and serotonin receptor modulators. The bromine substituent enhances metabolic resistance in resulting drug candidates. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity.
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