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7-bromo-3-chlorobenzo[d]isoxazole
$400.00
CAS No.: 1260677-07-3
Catalog No.: LT0074
Purity: 95%
MF: C7H3BrClNO
MW: 232.464
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=CC=2C(=NOC21)Cl
Catalog No.: LT0074
Purity: 95%
MF: C7H3BrClNO
MW: 232.464
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=CC=2C(=NOC21)Cl
CAS NO.: 1260677-07-3;7-bromo-3-chlorobenzo[d]isoxazole. PROPERTIES: This bromochlorinated heterocycle presents as a white crystalline solid with a molecular weight of approximately 254.5 g/mol. The 7-bromo-3-chlorobenzo[d]isoxazole combines bromine and chlorine substituents on an isoxazole ring. It exhibits limited aqueous solubility but good dissolution in polar aprotic solvents like DMSO and DMF. Stability characterization reveals sensitivity to nucleophilic aromatic substitution and base-catalyzed ring-opening, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause mild irritation requiring thorough washing. Inhalation may induce respiratory tract irritation; treatment includes fresh air and medical evaluation. Eye exposure requires extended rinsing and possible corticosteroid application. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 7-bromo-3-chlorobenzo[d]isoxazole functions as a key intermediate in the synthesis of various pharmaceuticals. Its isoxazole framework provides opportunities for directed metalation and cross-coupling reactions. Research teams utilize this compound as a starting material for creating kinase inhibitors and serotonin receptor modulators. The bromine and chlorine substituents enhance metabolic resistance and binding affinity in resulting drug candidates. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity.
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