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methyl 5-amino-1H-benzo[d]imidazole-2-carboxylate hydrochloride
$375.00
CAS No.: 2044704-79-0
Catalog No.: 192604
Purity: 95%
MF: C9H10ClN3O2
MW: 227.651
Storage: 2-8 degree Celsius
SMILES: Cl.NC1=CC2=C(NC(=N2)C(=O)OC)C=C1
Catalog No.: 192604
Purity: 95%
MF: C9H10ClN3O2
MW: 227.651
Storage: 2-8 degree Celsius
SMILES: Cl.NC1=CC2=C(NC(=N2)C(=O)OC)C=C1
methyl 5-amino-1H-benzo[d]imidazole-2-carboxylate hydrochloride; CAS No.: 2044704-79-0; methyl 5-amino-1H-benzo[d]imidazole-2-carboxylate hydrochloride. PROPERTIES: methyl 5-amino-1H-benzo[d]imidazole-2-carboxylate hydrochloride is a white to off-white crystalline powder with a molecular weight of 228.64 g/mol. It has a melting point between 230-235 C (hydrochloride salt) and is freely soluble in water. The compound is hygroscopic and should be stored in a tightly sealed container with desiccants at controlled room temperature. Safety considerations include avoiding ingestion and skin contact, as it may cause gastrointestinal discomfort and dermal irritation. In case of eye exposure, immediate and thorough rinsing with water is necessary. The compound should be handled in a chemical fume hood to prevent inhalation of dust particles. APPLICATIONS: methyl 5-amino-1H-benzo[d]imidazole-2-carboxylate hydrochloride is primarily used in pharmaceutical development as a prodrug intermediate. The methyl ester allows for controlled release of the active carboxylic acid upon administration, as described in drug delivery systems literature. In oncology research, it serves as a building block for creating kinase inhibitors where the benzimidazole scaffold enhances ATP competitive binding, as reported in medicinal chemistry studies. Additionally, it is utilized in agrochemical formulations as a precursor for creating fungicides targeting fungal kinase pathways, where the benzimidazole ring system interacts with fungal enzymes, as detailed in pesticide chemistry publications. The compound also finds application in materials science as a monomer for creating fluorescent polymers, where the benzimidazole structure contributes to photoluminescent properties, as outlined in polymer chemistry research. Furthermore, it is employed in analytical chemistry as a chiral resolving agent for separating enantiomers of pharmaceutical compounds, where the benzimidazole framework forms diastereomeric complexes with racemic mixtures, as described in separation science literature. Its reactivity makes it suitable for creating novel heterocycles through nucleophilic aromatic substitution reactions in chemical biology applications, as detailed in heterocyclic chemistry research.
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