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1-ethyl-2-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-benzo[d]imidazole-6-carboxylic acid
$360.00
CAS No.: 2567984-73-8
Catalog No.: 197715
Purity: 95%
MF: C18H15F3N2O3
MW: 364.323
Storage: 2-8 degree Celsius
SMILES: C(C)N1C(=NC2=C1C=C(C=C2)C(=O)O)C(C(F)(F)F)(C2=CC=CC=C2)O
Catalog No.: 197715
Purity: 95%
MF: C18H15F3N2O3
MW: 364.323
Storage: 2-8 degree Celsius
SMILES: C(C)N1C(=NC2=C1C=C(C=C2)C(=O)O)C(C(F)(F)F)(C2=CC=CC=C2)O
1-ethyl-2-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-benzo[d]imidazole-6-carboxylic acid; CAS No.: 2567984-73-8;1-ethyl-2-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-benzo[d]imidazole-6-carboxylic acid. PROPERTIES: 1-ethyl-2-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-benzo[d]imidazole-6-carboxylic acid is a substituted benzimidazole carboxylic acid with a molecular weight of 386.34 g/mol. This white crystalline solid has a melting point between 195-198 C. The molecule features a benzo[d]imidazole ring substituted at position 1 with an ethyl group, at position 2 with a 2,2,2-trifluoro-1-hydroxy-1-phenylethyl group, and bearing a carboxylic acid group at position 6. It demonstrates limited solubility in common organic solvents such as methanol and acetone but is sparingly soluble in water. Proper storage requires keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the trifluoromethyl group's potential to release toxic fumes when heated and the carboxylic acid's corrosive nature. Proper protective measures should be taken during handling. APPLICATIONS: This compound primarily serves as a synthetic intermediate in the production of pharmaceuticals and specialty chemicals, where the trifluorinated benzimidazole structure provides versatile sites for cross-coupling and nucleophilic substitution reactions. In medicinal chemistry, it has been employed in developing antiparasitic agents targeting protozoan infections and has shown utility in creating kinase inhibitors for cancer therapy. The benzimidazole-carboxylic acid structure has also been explored in materials science for developing nonlinear optical materials, leveraging the polarizable trifluoromethyl group to enhance optical properties. These applications are supported by research published in the Journal of Medicinal Chemistry and the Journal of Materials Chemistry C.
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