tert-butyl 3-(2-phenylacetyl)azetidine-1-carboxylate
$665.00
CAS No.: 1402238-44-1
Catalog No.: 195295
Purity: 95%
MF: C16H21NO3
MW: 275.348
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)CC(=O)C1CN(C1)C(=O)OC(C)(C)C
Catalog No.: 195295
Purity: 95%
MF: C16H21NO3
MW: 275.348
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)CC(=O)C1CN(C1)C(=O)OC(C)(C)C
tert-butyl 3-(2-phenylacetyl)azetidine-1-carboxylate; CAS No.: 1402238-44-1; tert-butyl 3-(2-phenylacetyl)azetidine-1-carboxylate. PROPERTIES: tert-butyl 3-(2-phenylacetyl)azetidine-1-carboxylate appears as a colorless to pale yellow liquid with a slight odor. Its molecular formula is C16H19NO3, corresponding to a molecular weight of approximately 277.33 g/mol. The compound exhibits a boiling point around 160-165 C at 760 mmHg and a density of about 1.15 g/cm? at 25 C. It demonstrates moderate solubility in common organic solvents such as methanol, ethyl acetate, and dichloromethane while being sparingly soluble in water. The substance is sensitive to acid and base hydrolysis, which may cleave the ester and amide bonds. Proper storage requires keeping it in a tightly sealed, amber glass container in a cool, dry location away from direct sunlight and heat sources. The temperature should be maintained below 10 C if possible. Safety precautions include using chemical-resistant gloves, safety goggles, and lab coats to prevent skin absorption and inhalation of vapors. The compound may cause skin and eye irritation, and accidental ingestion may be harmful. In case of exposure, immediate rinsing with water and medical consultation is recommended. APPLICATIONS: tert-butyl 3-(2-phenylacetyl)azetidine-1-carboxylate serves as a valuable intermediate in the synthesis of pharmaceuticals, particularly in the preparation of certain antidepressants and antipsychotics. Its azetidine and phenylacetyl groups provide structural features important for receptor binding and bioactivity. In materials science, it functions as a building block for creating chiral ligands and catalysts used in asymmetric synthesis. Additionally, it finds application in the development of fluorescent probes for bioimaging, where its phenylacetyl group allows for selective labeling of biological targets. The compound is also employed in the synthesis of agrochemicals, though specific applications in this area are limited to non-agricultural research settings.
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