3-methyl-1H-pyrazole-5-carboxylic acid hydrochloride
$345.00
CAS No.: 696-22-0
Catalog No.: 196350
Purity: 95%
MF: C5H7ClN2O2
MW: 162.576
Storage: 2-8 degree Celsius
SMILES: Cl.CC1=NNC(=C1)C(=O)O
Catalog No.: 196350
Purity: 95%
MF: C5H7ClN2O2
MW: 162.576
Storage: 2-8 degree Celsius
SMILES: Cl.CC1=NNC(=C1)C(=O)O
3-methyl-1H-pyrazole-5-carboxylic acid hydrochloride; CAS No.: 696-22-0; 3-methyl-1H-pyrazole-5-carboxylic acid hydrochloride. PROPERTIES: This compound presents a 3-methyl-1H-pyrazole-5-carboxylic acid hydrochloride structure, combining a methyl substituent and a pyrazole carboxylic acid group, and presented as a hydrochloride salt. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 140.1 g/mol (C5H5ClN2O2). The melting point ranges between 150-155 C, and it exhibits good solubility in water and common organic solvents like ethanol and methanol. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 3-Methyl-1H-pyrazole-5-carboxylic acid hydrochloride serves as a specialized intermediate in pharmaceutical research. Its 3-methyl-1H-pyrazole-5-carboxylic acid hydrochloride structure enables diverse reactivity patterns, including esterification, amide bond formation, and nucleophilic substitution at the pyrazole ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The methyl group provides steric and electronic effects that influence binding interactions with biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 3-methyl-1H-pyrazole-5-carboxylic acid hydrochloride scaffold for improved biological activity and target engagement.
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