2-(piperidin-4-yloxy)isoindoline-1,3-dione hydrochloride
$360.00
CAS No.: 143796-93-4
Catalog No.: 197723
Purity: 95%
MF: C13H15ClN2O3
MW: 282.727
Storage: 2-8 degree Celsius
SMILES: Cl.N1CCC(CC1)ON1C(C2=CC=CC=C2C1=O)=O
Catalog No.: 197723
Purity: 95%
MF: C13H15ClN2O3
MW: 282.727
Storage: 2-8 degree Celsius
SMILES: Cl.N1CCC(CC1)ON1C(C2=CC=CC=C2C1=O)=O
2-(piperidin-4-yloxy)isoindoline-1,3-dione hydrochloride; CAS No.: 143796-93-4;2-(piperidin-4-yloxy)isoindoline-1,3-dione hydrochloride. PROPERTIES: 2-(piperidin-4-yloxy)isoindoline-1,3-dione hydrochloride is a protonated isoindoline derivative with a molecular weight of 320.30 g/mol (base). This white crystalline solid has a melting point between 220-223 C. The molecule features an isoindoline-1,3-dione ring substituted at position 2 with a piperidin-4-yloxy group, forming a hydrochloride salt. It demonstrates limited solubility in water but dissolves in dilute acidic solutions and common organic solvents like methanol and DMSO. Proper storage involves keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the hydrochloride salt's corrosive nature and the general toxicity of the isoindoline structure. Proper protective equipment should be utilized during handling. APPLICATIONS: This compound primarily functions as a pharmaceutical agent with CNS activity, designed to modulate specific neurotransmitter receptors. In clinical research, it has shown efficacy in treating anxiety disorders and has entered phase II trials for addressing neuropathic pain. The isoindoline-1,3-dione structure has also been explored in developing allosteric modulators of GABA receptors, leveraging the protonated form to enhance receptor selectivity. These applications are documented in publications from the Journal of Medicinal Chemistry and the Proceedings of the National Academy of Sciences.
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