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2-cyclopropyl-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
$400.00
CAS No.: 356576-44-8
Catalog No.: 197726
Purity: 95%
MF: C12H9NO4
MW: 231.207
Storage: 2-8 degree Celsius
SMILES: C1(CC1)N1C(C2=CC=C(C=C2C1=O)C(=O)O)=O
Catalog No.: 197726
Purity: 95%
MF: C12H9NO4
MW: 231.207
Storage: 2-8 degree Celsius
SMILES: C1(CC1)N1C(C2=CC=C(C=C2C1=O)C(=O)O)=O
2-cyclopropyl-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid; CAS No.: 356576-44-8;2-cyclopropyl-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid. PROPERTIES: 2-cyclopropyl-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid is a substituted isoindole derivative with a molecular weight of 257.24 g/mol. This white crystalline solid has a melting point between 185-188 C. The molecule features an isoindole ring system with dihydro substitution at positions 2 and 3, dioxo groups at positions 1 and 3, a cyclopropyl group at position 2, and a carboxylic acid group at position 5. It demonstrates limited solubility in common organic solvents such as methanol and acetone but is sparingly soluble in water. Proper storage requires keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the carboxylic acid's corrosive nature and the general toxicity of the isoindole structure. Proper protective measures should be taken during handling. APPLICATIONS: This compound primarily serves as a synthetic intermediate in the production of pharmaceuticals and specialty chemicals, where the substituted isoindole structure provides versatile sites for cross-coupling and nucleophilic substitution reactions. In medicinal chemistry, it has been employed in developing antiparasitic agents targeting protozoan infections and has shown utility in creating kinase inhibitors for cancer therapy. The isoindole-carboxylic acid structure has also been explored in materials science for developing nonlinear optical materials, leveraging the polarizable cyclopropyl group to enhance optical properties. These applications are supported by research published in the Journal of Medicinal Chemistry and the Journal of Materials Chemistry C.
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