3-fluoro-4-iodoanisole
$600.00
CAS No.: 458-51-5
Catalog No.: 194008
Purity: 95%
MF: C7H6FIO
MW: 252.026
Storage: 2-8 degree Celsius
SMILES: FC=1C=C(C=CC1I)OC
Catalog No.: 194008
Purity: 95%
MF: C7H6FIO
MW: 252.026
Storage: 2-8 degree Celsius
SMILES: FC=1C=C(C=CC1I)OC
3-fluoro-4-iodoanisole; CAS No.: 458-51-5; 3-fluoro-4-iodoanisole. PROPERTIES: 3-fluoro-4-iodoanisole is a halogenated aromatic ether with a molecular weight of approximately 264.0 g/mol. It typically exists as a colorless to pale yellow liquid with a characteristic anisole-like odor. The substance has a boiling point in the range of 140-145 C and a density of approximately 1.55 g/cm?. It exhibits moderate solubility in organic solvents such as diethyl ether, chloroform, and hexane, but is sparingly soluble in water. Proper storage requires a cool, dry environment in sealed containers, preferably under nitrogen to prevent potential oxidation. Safety considerations include classification as harmful if swallowed, causing skin irritation, and may cause eye irritation. Standard laboratory PPE is recommended. Occupational exposure follows general OSHA guidelines for anisoles. APPLICATIONS: 3-fluoro-4-iodoanisole serves as a valuable cross-coupling partner in Suzuki-Miyaura reactions, with the iodine handle enabling efficient formation of carbon-carbon bonds. The fluoride substituent provides optimal electronic effects for transition metal catalysis. In pharmaceutical synthesis, the compound is utilized in the preparation of serotonin receptor modulators, where the anisole ether group enhances metabolic stability. The Journal of Organic Chemistry often features studies employing similar iodinated arenes in cross-coupling methodologies. Additionally, 3-fluoro-4-iodoanisole functions as a building block in the synthesis of agrochemical intermediates, though this application is outside the specified scope. The compound can undergo direct metalation reactions at the ortho position relative to the fluoride, enabling the introduction of additional substituents for medicinal chemistry applications. Recent advances in C-H activation chemistry have expanded the utility of this anisole derivative in forming complex aromatic architectures for drug discovery programs.
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