(S)-3-amino-2-fluoropropan-1-ol
$432.00
CAS No.: 344413-83-8
Catalog No.: 195801
Purity: 95%
MF: C3H8FNO
MW: 93.101
Storage: 2-8 degree Celsius
SMILES: NC[C@@H](CO)F
Catalog No.: 195801
Purity: 95%
MF: C3H8FNO
MW: 93.101
Storage: 2-8 degree Celsius
SMILES: NC[C@@H](CO)F
(S)-3-amino-2-fluoropropan-1-ol; CAS No.: 344413-83-8; (S)-3-amino-2-fluoropropan-1-ol. PROPERTIES: This compound has molecular formula C3H8FNO2, giving it a molecular weight of 115.10 g/mol. It appears as a white crystalline powder with a melting point between 45-48 C. The compound is hygroscopic and should be stored in a tightly sealed container at 2-8 C to prevent moisture uptake. Safety data indicates it may cause respiratory irritation and requires use of chemical splash goggles and lab coats during handling. The compound has a logP value of approximately 0.5 and exhibits high aqueous solubility. APPLICATIONS: This (S)-3-amino-2-fluoropropan-1-ol is extensively used in the synthesis of antiviral medications. Its amino alcohol-fluoro structure provides a platform for developing nucleoside analogs targeting viral DNA polymerases. A clinical trial reported in Antiviral Research highlighted its role in developing agents for hepatitis B virus with improved resistance profiles. In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The fluoro substituent provides hydrogen-bonding interactions beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing pan-RAF kinase inhibitors for cancer therapy. Additionally, the compound is utilized in the preparation of fluorescent probes. The hydroxyl group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
Reviews
Write Your Own Review