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(R)-2-aminopentanoic acid; CAS No.: 2013-12-9; (R)-2-aminopentanoic acid. PROPERTIES: This chiral amino acid features molecular formula C?H??NO? with molecular weight 117.15 g/mol. It typically exists as a white crystalline powder. Soluble in polar protic solvents like methanol and water. Melting point approximately 140-145 C. Exhibits IR absorption for carboxylic acid (~2900-2500 cm??) and amine groups (~3300-3000 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, (R)-2-aminopentanoic acid should be stored at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a chiral amino acid, (R)-2-aminopentanoic acid is predominantly utilized in the synthesis of peptide-based therapeutics. It serves as a key building block for constructing bioactive peptides with enhanced conformational stability, particularly in the development of enzyme inhibitors targeting proteases (Journal of Medicinal Chemistry). Additionally, the compound participates in the synthesis of fluorescent probes for bioimaging applications, where its amino acid functionality enables conjugation to biomolecules via amide bond formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyamino acid hydrogels with tunable mechanical properties, where the chiral center influences gelation behavior and biocompatibility (Biomacromolecules). Furthermore, the compound serves as a starting material in the development of chiral ligands for asymmetric catalysis, where its amino acid structure provides valuable stereoinduction in transition metal complexes (Catalysis Science & Technology).