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methyl 2,2-difluoropropanoate; CAS No.: 38650-84-9; methyl 2,2-difluoropropanoate. PROPERTIES: This compound is a methyl 2,2-difluoropropanoate appearing as colorless liquid. Its molecular weight is approximately 116.08 g/mol. It has characteristic mild ester odor. The compound is moderately soluble in common organic solvents like ether and chloroform. It shows good stability under normal conditions but may undergo hydrolysis upon exposure to strong bases. Store in tightly sealed containers below 30 C. Protect from heat and strong bases. Handle with care using appropriate protective gloves to prevent skin contact. APPLICATIONS: methyl 2,2-difluoropropanoate is utilized in organic synthesis as difluoroethylating agent as detailed in Synthetic Communications. It's employed in preparation of certain antifungal compounds mentioned in Journal of Medicinal Chemistry. Additionally, this compound serves as intermediate for synthesizing difluorinated pharmaceuticals reported in Organic & Biomolecular Chemistry. The difluoro group provides valuable electron-withdrawing effect beneficial in drug design applications.