2-chloro-N-(methylsulfonyl)acetamide; CAS No.: 202658-88-6; 2-chloro-N-(methylsulfonyl)acetamide. PROPERTIES: 2-chloro-N-(methylsulfonyl)acetamide is a crystalline solid. Its molecular formula is C4H7ClNO2S, and the molecular weight is approximately 178.62 g/mol. The compound has a melting point of approximately 70-72 C. It is moderately soluble in common organic solvents such as ethyl acetate and tetrahydrofuran, but is poorly soluble in water. For proper storage, it should be kept in a sealed container at room temperature, away from heat and direct sunlight. As a compound containing a chloro group, an amide group, and a sulfonyl group, it may exhibit certain reactivity and stability. When handling it, protective gloves and eye protection should be worn. In case of accidental contact with skin or eyes, immediate rinsing with water is necessary. APPLICATIONS: In organic synthesis, 2-chloro-N-(methylsulfonyl)acetamide serves as a valuable intermediate. The chloro group provides a site for substitution reactions. The amide and sulfonyl groups can undergo various reactions such as hydrolysis and alkylation. In the pharmaceutical industry, derivatives of this compound can be explored as potential drug candidates. For example, in the development of certain anti-inflammatory drugs, the structure of 2-chloro-N-(methylsulfonyl)acetamide can be modified to enhance the drug's efficacy and reduce side effects (as reported in medicinal chemistry journals). Additionally, in the field of materials science, it can be incorporated into the synthesis of functional materials such as liquid crystals or organic semiconductors, where its structure can influence the material's electronic and optical properties (as mentioned in materials chemistry research papers).