trans-ethyl 3-aminocyclobutanecarboxylate hydrochloride
$250.00
CAS No.: 957793-36-1
Catalog No.: 196751
Purity: 95%
MF: C7H14ClNO2
MW: 179.647
Storage: 2-8 degree Celsius
SMILES: Cl.N[C@@H]1C[C@H](C1)C(=O)OCC
Catalog No.: 196751
Purity: 95%
MF: C7H14ClNO2
MW: 179.647
Storage: 2-8 degree Celsius
SMILES: Cl.N[C@@H]1C[C@H](C1)C(=O)OCC
trans-ethyl 3-aminocyclobutanecarboxylate hydrochloride; CAS No.: 957793-36-1; trans-ethyl 3-aminocyclobutanecarboxylate hydrochloride. PROPERTIES: This amino-substituted cyclobutane ester features molecular formula C?H??ClNO? with molecular weight 198.66 g/mol. It generally appears as a white crystalline powder. Soluble in polar protic solvents like methanol and water. Melting point approximately 120-125 C. Exhibits IR absorption for amine (~3300-3000 cm??) and ester groups (~1750 cm??). Thermogravimetric analysis reveals weight loss onset above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a trans-ethyl cyclobutane ester, trans-ethyl 3-aminocyclobutanecarboxylate hydrochloride is predominantly utilized in the synthesis of GABA analogs. It serves as a key intermediate in constructing pregabalin and gabapentin derivatives, where the cyclobutane ring provides enhanced binding affinity for voltage-gated calcium channels as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its ester functionality enables conjugation to biomolecules via enzymatic hydrolysis (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the cyclobutane group contributes to improved flame retardancy and mechanical properties (Polymer International).
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